The T2 Laboratories explosion and fire occurred on December 19, 2007, in Jacksonville, Florida, resulting in the deaths of four people and the injury of fourteen others.

[3][4] The explosion's force was equivalent to detonating 1,400 lb (640 kg)[5] of TNT and it spread debris up to 1 mi (1.6 km) from the plant.

[6] Following the explosion, every HAZMAT unit in Jacksonville and over 100 firefighters fought the ensuing blaze, which a spokesman termed a "hellish inferno".

[2] The blast killed Robert Scott Gallagher, 49; Charles Budds Bolchoz, 48; Karey Renard Henry, 35; and Parrish Lamar Ashley, 36.

Pressures rapidly reached 400 psi (28 bar), bursting the reactor's rupture disc, but this was insufficient to slow the runaway reaction.