The TDR Targets database is a bioinformatics project that seeks to exploit the availability of diverse genomic and chemical datasets to facilitate the identification and prioritization of drugs and drug targets in neglected disease pathogens.

[2] TDR in the name of the database stands from the popular abbreviation for a special programme within the World Health Organization, whose focus is Tropical Disease Research.

[3] When prioritizing genes, individual database queries are used to specify one or more desirable or undesirable criteria.

The database currently hosts information for 21 bacterial and eukaryotic pathogens, and for > 2 million bioactive compounds.

The database has seen six major releases since its launch in 2007, which coincided with expansion of phylogenetic coverage (e.g. inclusion of helminth genomes in release 2), incorporation of new functionalities (e.g. chemical similarity and substructure searches in release 4), major data updates to keep the database in sync with upstream data providers (in release 5), and the incorporation of a multilayer network model [5] to guide Drug repositioning through nice user-friendly visualizations (in release 6).