In enzymology, a tRNA guanosine-2'-O-methyltransferase (EC 2.1.1.34) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing 2'-O-methylguanosine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.
The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1V2X and 1ZJR.
This EC 2.1 enzyme-related article is a stub.