She is the co-founder, creative director and producer of the long-running comedy festival SF Sketchfest in San Francisco.

She has appeared as a guest star in series including Bones, Better Off Ted, How I Met Your Mother, Hot in Cleveland, and Psych.

After a decade of voicing Korra in both the series and several video games, Varney later stepped down from the role with her final outing as the character being in Nickelodeon Kart Racers 3: Slime Speedway in 2022.

[8] Varney was a main cast member on IFC's Stan Against Evil, playing Sheriff Evie Barret.

[12] In 2005, Varney replaced Lisa Kushell as the host of the TBS cooking and entertainment show Dinner and a Movie.

She appeared with Paul Gilmartin and Claud Mann in each episode, introducing films and injecting humor during the preparation of a creative dinner for some themes.

Varney has written and performed several comedic audio commentaries for films along with fellow SF Sketchfest co-founder Cole Stratton.

She has performed in Rifftrax commentaries for the following films: In March 2012, Varney launched a podcast titled The JV Club, hosted on Nerdist.com[13] from 2012 to 2018.

[18] She has appeared on the podcast Hello from the Magic Tavern as the character Braidwynn the Warrior Elf, who disguises herself as Crone Bakeress.