Tamapin is a toxin from the Indian Red Scorpion (Hottentotta tamulus), which is a selective and potent blocker of SK2 channels.
[1] The target of tamapin is the small conductance calcium-dependent potassium (SK) channel.
[1] Despite completely different sequences, Apamin (a bee venom toxin) and tamapin share at least in part, the same binding sites on rat brain synaptosomes.
Previous studies showed that the effect of tamapin is largely reversible and depends on time and concentration.
The Indian red scorpion (Hottentotta tamulus) causes a large number of deaths annually especially among young children.