Tantalum(V) bromide is the inorganic compound with the formula Ta2Br10.

[2] It is a diamagnetic, orange solid that hydrolyses readily.

The compound adopts an edge-shared bioctahedral structure, which means that two TaBr5 units are joined by a pair of bromide bridges.

The bromides of the early metals are sometimes preferred to the chlorides because of the relative ease of handling liquid bromine vs gaseous chlorine.

[4] It can also be produced from the more accessible oxide by metathesis using aluminium tribromide: Carbothermal reduction of the oxide in the presence of bromine has also been employed, the byproduct being COBr2.