Its name is derived from the distance early surveyors estimated it was from the Raritan River on the historic Kings Highway, now Route 27.

It flows through the T&C Preservation Land adjacent to the Delaware and Raritan Canal and drains into the Millstone River at 40°27′28″N 74°35′29″W / 40.45778°N 74.59139°W / 40.45778; -74.59139.

Ten Mile Run is home to a multitude of small fishes with sizes ranging from 1 to 6 inches.

Its tributaries in the residential development are completely rocky and come from springs routed underground through storm drainage systems.

Some shale cliffs are present near the stream, similar to but smaller than the ones lining the Nine Mile Run.