tert-Butyldimethylsilyl chloride is an organosilicon compound with the formula (Me3C)Me2SiCl (Me = CH3).

It is commonly abbreviated as TBSCl or TBDMSCl.

It is a colorless or white solid that is soluble in many organic solvents but reacts with water and alcohols.

The compound is used to protect alcohols in organic synthesis.

[4] The triflate derivative (Me3C)Me2SiOTf is used similarly but is more reactive.