8031252463ENSG00000138336ENSMUSG00000047146Q8NFU7Q3URK3NM_030625NM_001253857NM_027384NP_085128NP_001240786NP_001393310NP_001393311NP_001393312Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene.

[7][8] TET1 was first discovered in a 61-year-old patient with a rare variation of t(10;11)(q22;q23) acute myeloid leukemia (AML) as a zinc-finger binding protein (specifically on the CXXC domain) that fuses to the gene MLL.

[17][18] The enzyme is also utilized as part of TET-Assisted Bisulfite Sequencing (TAB-seq) to quantify levels of hydroxymethylation in the genome and to distinguish 5-hydroxymethylcytosine (5hmc) from 5-methylcytosine (5mc) at single base resolution.

The technique was developed by Chuan He and rectifies the inability of traditional bisulfite sequencing to decipher between the two modified bases.

[24] A histone deacetylase inhibitor Trichostatin A increased levels of TET1 in breast cancer tissues but was a less effective tumor suppressor in patients with low TET1 expression.