[2] Before entering the game industry, Mizuguchi majored in literature at Nihon University's Faculty of Arts.

[3] One of the influences for Mizuguchi joining the game industry was a photograph of NASA's view VR headset.

"[3] Mizuguchi worked for Japanese game developer Sega from 1990 to 2003 and began his career – not on a game – but by designing arcade cabinets and an interactive 'ride' titled Megalopolis, combining then-embryonic 3D polygonal graphics and CGI (Computer-generated imagery) with the physical experience of Sega's hydraulic 'AS-1' motion simulator.

[4] Both Space Channel 5 and Rez are referenced in modern gaming media as essential and influential to the development of the modern wave of music-rhythm games, with Harmonix Music Systems co-founder, Alex Rigopulos citing Mizuguchi as an influence in Harmonix's history.

On November 7, 2006, he also produced Lumines II for PSP, the sequel to the popular original (this time supplementing the original score with heavy integration of music videos), and a shooter/puzzle hybrid game called Every Extend Extra (a heavily modified 'synesthesia' update to an existing PC freeware title, Every Extend, by indie developer "Omega"), which was released on August 7, 2006.

His company's latest game is Lumines Electronic Symphony, which launched on February 22, 2012, and currently holds an aggregate score of 83 out of 100 with at least 45 out of 50 reviews registering as 'positive.'

Mizuguchi put an all-new team in charge of the project, with the task of revitalizing the series, and completing the game in time for the PlayStation Vita's North American and European launch.

He is known for collaborating with various DJs and music producers for the soundtracks of his games, including Ken Ishii, Tsuyoshi Suzuki, and Mondo Grosso.

[citation needed] On September 20, 2012, a news article reported that "Tetsuya Mizuguchi has stepped away from games production, for the time being, taking on a more delegatory role within Q Entertainment.

[12] Mizuguchi had wanted for many years to produce a music-based game around Tetris, but its licensing had been held by Electronic Arts, making it difficult to use, which led him to develop Lumines instead.

Mizuguchi said that the goal of the game was "to amplify and enhance that same magical feeling where you just can’t get it out of your head, and not just the falling shapes, but all the visuals, the sounds, the music".

[14][13] In 2006, Mizuguchi pursued his love of technology and electronic music, founding the band Genki Rockets with a consistent group of collaborators, including songwriter and producer Kenji Tamai, as well as singers Rei Yasuda and Nami Miyahara.

Mizuguchi would write all of the album's lyrics and contribute melodic ideas to Tamai, who would then work on the tracks in the studio.