[2] The route travels northeast through small towns in the western Panhandle, reaching an intersection with US 385 in Hereford.

[6] The route passes through Panhandle and Pampa, before beginning a 10-mile (16 km) concurrency with US 83 in Hemphill County.

[7] The two routes split north of Canadian,[8] with US 60 travelling northeast to the Oklahoma state line near Higgins in Lipscomb County.

By 1920, the entire US 60 route had been renumbered as State Highway 33, or its spur SH 33A, with the northeastern portion also following the AT&SF Railway.

[10] It was renumbered as US 60 on June 8, 1931, when the route was extended to Los Angeles, California, to make it a coast-to-coast highway.