Loop 49 (also called Toll 49) is a currently 32-mile (51 km) circular freeway that, along with I-20, will encircle the city of Tyler and serve other various communities in Northeast Texas upon its completion.

Construction then continued east, with Segment 2, which extends 2.0 miles (3.2 km) from US 69 to FM 756 (Paluxy Dr), opening to traffic January 7, 2008.

This section of the tollway, which was funded by Proposition 14 highway bonds, approved by Texas voters in 2003, opened to traffic June 28, 2012[7] after nearly 29 months of construction,[8] bringing the total length of the loop to 9.6 miles (15.4 km).

This segment was constructed using federal funds from the American Recovery and Reinvestment Act of 2009, after the Texas Transportation Commission approved its status as a stimulus project on March 5, 2009.

In an effort to speed completion of the west side of Loop 49 and connect it to Interstate 20, the NET RMA approved a plan in August 2009 to develop Segment 3B, the longest section of the toll road at 9.7 miles (15.6 km), using a nontraditional "design/build" process.

On February 28, 2013, the Texas Transportation Commission voted to transfer ownership and maintenance of Loop 49 from TxDOT to the NET RMA.

The environmental coordination stage of planning, with various state and federal approvals was completed, with construction beginning in 2016, and the segment opening to traffic on November 7, 2018.

Segment 6 is planned to complete the eastern portion of Loop 49, connecting SH 110 near Whitehouse to I-20 near the Smith-Gregg County line.