Dunton explains in his autobiography Life and Errors he had an inspiration for the title one day while he was walking home that he would "not exchange for 50 guineas."
[6] The "most nice and curious questions" ran from natural sciences to religion to literature to politics.
The Athenian Gazette, as these first two issues were called, produced such a large readership that an increase in their Society membership of "experts" was required.
As readership increased and the amount of inquiries became overwhelming, they added another member, Dunton's brother-in-law the poet Reverend Samuel Wesley.
[9] Because Dunton's "answers to correspondents" were "universally received" his "Children of the Brain" were being plagiarized by a copycat publication called The Lacedemonian Mercury.
[12] Dunton was surprised one day early on into his "question project" with a letter that came from a "gentle-woman" who wish to know if ladies could submit inquiries also.
One thing lead to another and on 28 February 1693 The Ladies' Mercury, a spin-off, started its own publication, a periodical exclusively for women.
[15] Additionally, analysis of the questions in the Athenian Mercury has been focused on the political and scientific content portrayed by the authors.