The film stars Cummings, Sofía Vergara, Toby Kebbell, James Marsden, Deon Cole, Lucy Punch, Beanie Feldstein and Cecily Strong.

Stoic and uptight, university neurologist Julia Brizendine compares the female and male brain.

Fearing their relationship has grown dull, Lisa tries to spice things up by going on a date and getting high.

They break up when Lexi insists examining a tumor on his back, which turns out to be benign.

Zoe Green-Basker, a sales manager at an advertising company, resents gender stereotyping.

One day, a patient named Kevin Avery flirts with her before entering the MRI machine.

Then when Kevin stops by her campus office because she won't return his texts, Brizendine tells him off and says she is fine without him.

Greg is surprised to find a contractor working on the bathroom renovation and they get into a physical fight.

She admits that female and male brains are different, and that showing emotions is not a sign of weakness, giving a TED talk about it.