Behind him is a cross symbolizing his crucifixion, as well as was typical in a "Man of Sorrows" painting, a group of angels holding some of the other implements of the Arma Christi or "Instruments of the Passion" which were employed by Jesus to defeat Satan, i.e. the ladder used to take him down from the cross, the Spear of Longinus, which was used to pierce his side during his execution, the pillar to which he was bound while being whipped, the nails used to fasten him to the cross, the pincers utilized to extract the nails from the savior, and the sponge the Roman soldiers dipped in vinegar and offered him prior to his perishing.

Her descendant Pamela Margaret Stanley (later Lady Cunynghame of Milncraig) sold it at auction as by the workshop of Botticelli for £10,000 in 1963.

[4][5] The painting is from the artist's post-1492 period when he was greatly influenced by the Dominican friar and theocratic dictator of Florence, Girolamo Savonarola.

In 2009 it was reattributed to the master and in 2010 it was shown as part of the exhibition Botticelli: Likeness, Myth, Devotion at the Stadel Museum, in Frankfurt, Germany.

[7][8] On January 27, 2022, Man of Sorrows sold for $45.4 million US (with fees) at Sotheby's in New York City, just short of a year after another of the artist's works, Portrait of a Young Man Holding a Roundel, sold for $92.2 million US and set a record for the price paid for a work by the artist.