Virgin and Child with two Angels is a panel painting by the Italian Renaissance painter Sandro Botticelli.

[2] Owing to its comparatively poor condition, due to the peeling off of some tempera layers as well as some ancient restoration attempts, the painting had not unanimously been attributed to Botticelli himself: critics like Bernard Berenson, who had at first declared it to be genuine, later attributed it to Botticelli's workshop.

Today, art historians largely agree that it is indeed an early painting by Sandro Botticelli.

[1] Virgin and Child with two Angels was bought in London by Karl Trübner [fr] in 1904, from the heirs of Horatio Granville Murray-Stewart (1834–1904), former High Sheriff of Donegal.

It was inherited by the Strasbourg museum in 1908, together with other paintings from the Trübner collection, such as Van Everdingen's Nordic Landscape with a Castle on a Hill.