In 1796, some six years after Hahnemann first experienced the effect of Peruvian Bark Cinchona in 1790 he published an article under the title "Essay on a New Principle".

Wheeler appeared called the Organon of the Rational Art of Healing, published in the Everyman's Library series by J M Dent in London.

Below the title of the Book was written a small couplet from Gallert's poem - The truth we mortals need The All-wise slightly covered over The second edition of the Organon was published in the year 1819 when Hahnemann was living in Leipzig in Germany.

There is also an Italian translation of 1824 by Bernardo Quaranta "L'Organo della Medicina del dottor Samuel Hahnemann" printed in Naples.

On page 3 of the Italian translation of Organon 3, the following quotation from Seneca the Younger appears: "Non enim cuiquam mancipavi, nullius nomen fero: multum magnorum judicio credo, aliquid et meo vindico."

Hahnemann's miasm theory, deriving from his two volume work, The Chronic Diseases published the previous year (1828), was first alluded to in this edition.

This fifth Organon departed significantly in style and content from the four previous editions by making numerous references to metaphysical notions like the vital force, miasms and potency energy.

In a letter from Paris dated June 1, 1841 he states, "I am preparing the sixth edition of the Organon, to which I can only devote a few hours on Thursdays and Sundays.

"[11] However, in a letter to his publisher in Düsseldorf, dated 20 Feb 1842, he wrote, "I have now, after eighteen months of work, finished my sixth edition of my Organon, the most nearly perfect of all.