Elements of objects can be interacted with, such as pushing buttons, inserting and turning keys, or sliding sections around.

Items can be collected and examined from the player's inventory, which many include manipulation of that object to reveal secret chambers or the like.

As with previous games, The Room Three also has some puzzles made out of the classical element Null, which can bend reality.

There are optional puzzles scattered in the central hub that can be solved as to reach one of the game's alternate endings.

A journal written by the protagonist indicates that he is haunted by the events of The Room Two, and has tried to find answers via the Royal Institute.

The camera pulls back to reveal the train to be running on rails within an infinite maze within a globe in Grey Holm (The "Imprisoned" ending).

Awards, the Academy of Interactive Arts & Sciences nominated The Room Three for "Mobile Game of the Year".