The podcast consisted primarily of reviews and commentary on pop-culture phenomena such as movies, video games, television programs, and comic books.

Debuting on March 27, 2007, The Totally Rad Show was hosted by Alex Albrecht, Jeff Cannata, and Dan Trachtenberg, with episodes releasing once a week.

Occasionally, TRS produces special segments based on the hosts' coverage of trade shows, holiday celebrations, or group gaming sessions.

With the exception of on-location segments and show-opening parodies, the Totally Rad Show is filmed in front of a green screen in Alex's garage.

This allows the use of Chroma key to superimpose segment-specific backgrounds, gaming sessions, trailers and cut-scenes, as well as images of packaging or covers of the media referenced during the discussion.

Although cameraman/editor Mike Gaines (formerly Steve) does not appear onscreen, his voice is sometimes heard, and his presence is felt through creative, artistic or informative contributions to the recorded video.