Rose and Albrecht then discuss Digg stories from the previous week, with off-topic banter with each other and with Prager and camera operator Glenn McElhose.

The show begins with a short listing of the podcast's current sponsors, followed by a humorous fake advertisement (i.e. Bose's Noise Enhancing Headphones, "Days of our Prager", Cougars: Aged to Perfection, etc.).

The majority of the episode is dedicated to Rose and Albrecht discussing news items as well as providing personal commentary, anecdotes and unrelated banter.

[5] With the relaunch of Diggnation in 2024, the audio version of the feed[6] is distributed by Transistor to Apple Podcasts, Pocket Casts, Overcast, and other listening apps.

[9] Although hosting duties were typically split solely between Rose and Albrecht, a few "third-chair" guests were invited onto the program: Other guests included Chris Hansen, Adam Carolla, Ashton Kutcher, WWE Diva Candice Michelle, Gary Vaynerchuk, Rachel Maddow, Leo Laporte, Robert Rodriguez and Tony Hawk.

A spin-off show, The Digg Reel ran from January 2008 to September 2010, and was originally hosted by Jessica Corbin, followed by Andrew Bancroft.

The show featured the week's top user submitted videos in comparison to Diggnation's primary focus on news articles.