Named after the first documented uprising of transgender and queer people in United States history, the Compton's Cafeteria riot of 1966, the district encompasses six blocks in the southeastern Tenderloin, San Francisco, and crosses over Market Street to include two blocks of Sixth Street.
[8] District projects planned for 2020 include a coffee shop that will provide job training for local trans people of color.
Executive director Aria Sa'id explained that they did not wish to "continue honoring [Gene Compton] and his restaurant", as "he was a huge reason behind having drag queens, queer, and trans folks arrested".
[11][12] In May 2022, the district announced that they would be pulling out of Pride events sponsored by the City and County of San Francisco.
[14] In June 2022, the Board of Supervisors voted unanimously to designate the intersection of Turk and Taylor streets in the district as a historic landmark.