Ophiacodon (meaning "snake tooth") is an extinct genus of synapsid belonging to the family Ophiacodontidae that lived from the Late Carboniferous to the Early Permian in North America and Europe.

It was larger than most other tetrapods (four-limbed vertebrates) of its time, ranging from 1.6 to 3 metres (5.2 to 9.8 ft) in length and 26 to 230 kilograms (57 to 507 lb) in weight.

Anatomical features suggesting that it spent much of its time in the water include broad claws that seemed to be adaptations for paddling, thin jaws and numerous small teeth that seemed to be adapted for eating fish, and weakly developed bones, which are seen in many other secondarily aquatic tetrapods.

Several of these features are no longer thought to be evidence of an aquatic lifestyle; for example, broad claws are seen in most early tetrapods, even those that are known to have been almost exclusively terrestrial, and the long hindlimbs of Ophiacodon would not have been an effective means of propulsion because the feet were still relatively small and had little surface area over which to form a paddle.

Skeletons of Ophiacodon show a fast growth pattern called fibrolamellar bone (FLB), suggesting at least partial warm-bloodedness.