Thia-crown ether

In organic chemistry, thia-crown ethers are organosulfur compounds which are the thia analogues of crown ethers (cyclic polyethers).

Thia-crown ethers exhibit affinities for transition metals.

1,4,7-Trithiacyclononane (9-ane-S3) is a tridentate ligand and forms complexes with many metal ions, including those considered hard, such as copper(II) and iron(II).

Evaluation of antibacterial activities of some thia crown ethers indicated that they can be considered as inhibitors for S. aureus methicillin resistance and P. aeruginosa.

In addition, some of these compounds were screened for their antibacterial and antifungal activity on Klebsiella pneumoniae, Staphilococcus aureus, Pseudomanas aeruginosa and Candida albicans [5].

The structure of (CH 2 CH 2 S) 3 (9-ane-S3)
Structure of the silver complex of a thiacrown ether [Ag(18-ane-S6)] 2+ .