[1] Circulating fibrinogen binds these receptors on adjacent platelets, further strengthening the clot.

In humans, two TP receptor splice variants – TPα and TPβ – have so far been cloned.

Contrastly, TXA2 vascular tissue synthesis is stimulated by angiotensin II which promotes cyclooxygenase I's metabolism of arachidonic acid.

[6] TXA2 is very unstable in aqueous solution, since it is hydrated within about 30 seconds to the biologically inactive thromboxane B2.

[7] Due to its very short half life, TXA2 primarily functions as an autocrine or paracrine mediator in the nearby tissues surrounding its site of production.