1WYW, 2D07, 2RBA, 3UFJ, 3UO7, 3UOB, 4FNC, 4JGC, 4XEG, 4Z3A, 4Z47, 4Z7B, 4Z7Z, 5CYS6996545124ENSG00000139372n/aQ13569n/aNM_001008411NM_003211NM_001363612XM_006521630NP_003202NP_001350541n/aG/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene.

[7] The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family.

Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine.

[8] Later on, the crystal structure of the hTDG catalytic domain in complex with duplex DNA containing 5caC was published, which supports the role of TDG in mammalian 5-methylcytosine demethylation.

[9] Thymine-DNA glycosylase has been shown to interact with: Click on genes, proteins and metabolites below to link to respective articles.