Tierra Blanca Creek is an ephemeral stream about 75 mi (121 km) long, heading in Curry County, New Mexico, flowing east-northeast across northern portions of the Llano Estacado to join Palo Duro Creek to form the Prairie Dog Town Fork Red River southeast of Amarillo, Texas.

The creek's water levels are variable, and it is not unusual for some parts of the creek to be reduced to a small trickle or dry completely during frequent periods of drought in the semi-arid plateau of the northwestern Texas Panhandle.

At the same time, as the sole creek bed draining a large region with frequent violent thunderstorms, it is also the site of significant occasional Flash floods.

One theory suggests that the name refers to white deposits of Tertiary clay that are found along the sides of the valley.

[4] Another theory suggests that it was the exposed traces of white caliche along the valley walls that gave this stream its Spanish name.