TimeLogic was founded in 1981 by James W. (Jim) Lindelien and developed one of the first commercial hardware-accelerated tools for bioinformatics, an FPGA-accelerated version of the Smith-Waterman algorithm.
TimeLogic's DeCypher systems have expanded to provide accelerated implementations of the ubiquitous bioinformatics algorithms BLAST, Smith-Waterman, and HMMER using field programmable gate array (FPGA) technology.
[5][6][7] In 2002, the rice genome, the first completely sequenced crop,[8] was annotated using DeCypher FrameSearch "to detect and guide the correction of frameshifts caused by indels.
"[9] In 2004, a high throughput genomic approach to the study of horizontal gene transfer in plant-parasitic nematodes[10] was conducted using DeCypher Tera-BLAST, Timelogic's implementation of the BLAST algorithm.
[14] In 2011, a global assessment of the genomic variation in cattle was conducted using DeCypher Tera-BLAST "to accurately detect chromosomal positions of the SNP sites.