It is administered with ritonavir in combination therapy to treat HIV infection.

[4] Tipranavir should only be taken in combination with ritonavir and other antiretroviral drugs, and is not approved for treatment-naïve patients.

[2] Like lopinavir and atazanavir, it is very potent and is effective in salvage therapy for patients with drug resistance.

The drug has also been shown to cause increases in total cholesterol and triglycerides.

[2] Aptivus labeling has a black box warning regarding hepatotoxicity and intracranial hemorrhage.