During the 20th century, it was absorbed by the outward spread of the state capital, and is now a fully integrated part of the Guadalajara conurbation, lying only a few kilometers from the city center.

Lithologically, the municipality was formed in the Quaternary period and is composed of pumitic tobas (commonly known as pumice stone that are made up of explosion products such as lapillis, puzzolanas and ash.

The main industrial branch is manufacturing, handicrafts, papier-mache, glass, brass, pottery, yarn, mud, leather and wood.

Within the municipality are located several industrial parks, in which they house different national and transnational plants, such as: The name Tlaquepaque derives from Nahuatl and means "place above clay land".

Before the Spaniards arrived on these lands, the Toluquilla, Zalatitán, Coyula, Tateposco, Tlaquepaque, Tapechi (Tepetitlán), and Tequepexpan, formed with Tonalá a kingdom, ruled by a woman named Cihualpilli Tzapotzinco.

Representatives included Coyotl, Chitacotl, Tonatl, Xonatic, Cuauhuntin, and Oceotl from Tlaquepaque; Coyopitzantli from Tetlán; Timoac and Oxatl from Tzalatitán; Ipac from Atemaxac; and Tzacamitl from Ichcatlán.

The delegation presented Guzmán with gifts such as chickens, eggs, honey, avocados, onions, and fruits, expressing their willingness to welcome the Spaniards peacefully.

The name “Danza” was chosen in a raffle that included alternatives like Petra and Micaela, commemorating a dance she organized in honor of the Spaniards.

The imposed tribute included four loads of grass daily, ten Castilian chickens, ten loads of firewood, five laborers per week, thirty blankets, forty Tapatío cloaks, twenty pairs of quills, six loaves of salt, and two jugs of honey every two months, as well as 400 fanegas of corn and 20 fanegas of chili annually.

On the morning of 26 November 1810, Hidalgo made his entrance to San Pedro where he was presented with a feast, and in the afternoon he entered the capital triumphantly.

The priest Miguel Hidalgo y Costilla arrives in San Pedro Tlaquepaque, on Sunday, 25 November, from Atequiza Jalisco.

In the year of 1979 it was closed, and after being abandoned for a long time, the construction was acquired by the Municipal Administration of Tlaquepaque of Mr. Porfirio Cortés Silva in 1983; and rescued, renovated and modified in 1984 by the architect Alejandro Zhon, in order to carry out the Cultural Center "The Refuge" who was responsible for carrying out the rehabilitation work, which retained the original architecture of the building, highlighting its lengths corridors and large patios, making it a Cultural, Commercial, Craft and Tourist Center.

Its streets and walkers are adorned with various Casonas of the last century, in addition to colonial constructions, the Tapatío Tour arrives at the municipality on one of its routes.

The main plaza in the city centre, named after one of its dominating features, the larger-than-life statue of the "Father of Mexican Independence," Miguel Hidalgo y Costilla.

On the day of San Pedro itself, towering firework-festooned structures known as the Castillo ("castle") and Toro ("bull") are set alight.

[citation needed] Tlaquepaque is also known for its famous tepache, a partially fermented drink made with pineapple, brown sugar and water.