The line was originally constructed by the Ōji Electric Tram Company (王子電気軌道, Ōji-denki-kidō) as a part of their extensive network, with the oldest section still operating today opened in 1913.

Two Toden Arakawa trams (one in revenue earning service, the other undergoing brake testing) collided on June 13, 2006 near the Minowabashi terminus, injuring 27 people.

The Toden Arakawa Line operates in northern and eastern Tokyo outside the main tourist areas.

The terminus at Minowabashi is near the historical site of Edo's red-light district Yoshiwara which features a completely covered shopping street, several blocks long, in the once common "Ameyoko" style (a shōtengai).

In Haruki Murakami's novel Norwegian Wood, protagonist Toru Watanabe takes the line to near Ōtsuka Station: "I sat in the last seat and watched the ancient houses passing close to the window.