His most notable achievement was reaching the final of the 2010 Wimbledon Championships, completing consecutive upsets in the defeat of top seed and six-time champion Roger Federer in the quarterfinals, and of No.

He also played the longest ATP doubles match ever, with Lukáš Rosol, defeating Marco Chiudinelli and Stan Wawrinka in the first round of the 2013 Davis Cup 6–4, 5–7, 6–4, 6–7, 24–22.

He has met many Czech players from the National Hockey League and the 1998 Olympic gold medal team, including Martin Straka, Jaromír Jágr and Dominik Hašek.

In 2003, after several future and challenger wins, Berdych won his first ATP Tour match at the 2003 US Open, over Tomas Behrend in four sets, but lost in the next round to Juan Ignacio Chela.

After his run at the Olympics, he reached the fourth round of the 2004 US Open with victories over Jonas Björkman, Tuomas Ketola and Mikhail Youzhny, before losing to Tommy Haas in three sets.

He won his first ATP title at the Campionati Internazionali di Sicilia in Palermo, Italy, defeating David Ferrer in the semifinals and Filippo Volandri in the finals.

En route to the final, he beat Jiří Novák, second seed Guillermo Coria, Juan Carlos Ferrero, Gastón Gaudio, and Radek Štěpánek.

At Wimbledon, he made it to the quarterfinals in his best performance at a Grand Slam, defeating Nicolás Massú, Michaël Llodra, Hyung-Taik Lee, and 19th seed (35th-ranked) Jonas Björkman, before losing to Rafael Nadal in straight sets.

In the Canada Masters event, his first tournament since Wimbledon, as the 10th seed and defending quarterfinalist, he lost in the first round to Robin Haase, who was making his Canadian debut.

At the 2008 Miami Masters, Berdych made it to the semifinals, including a win over Juan Carlos Ferrero and not dropping a set en route, but he lost to Rafael Nadal.

He then won his only title of the year in the 2008 AIG Japan Open Tennis Championships, with wins over four top-20 players: Tommy Robredo, Fernando González, Andy Roddick, and Juan Martín del Potro in the finals.

In the Davis Cup first-round tie against France, he won the opening match, defeating top-ranked Frenchman Gilles Simon and joined Radek Štěpánek to beat French duo Richard Gasquet and Michaël Llodra.

He then represented Czech Republic at the 2010 ARAG World Team Cup and won all his three singles matches, but failed to reach the final after losing the tie against USA.

In the 2011 Sony Ericsson Open, Berdych reached the round of 16, after defeating Rubén Ramírez Hidalgo, Carlos Berlocq, and Florian Mayer, before falling to eventual finalist Rafael Nadal.

At the 2011 Open de Nice Côte d'Azur, Berdych reached his first semifinal of the clay season, before losing to eventual champion Nicolás Almagro in straight sets.

[31] Berdych's next tournament was the 2011 Shanghai Rolex Masters, where he beat defeating compatriot Radek Štěpánek, before falling to Feliciano López in straight sets.

He came into the year-end championships as the 7th seed and was placed in Group A along with Novak Djokovic, Andy Murray (Later replaced by Janko Tipsarević), and David Ferrer.

Berdych finished the tournament with a 4–0 singles record, defeating Grigor Dimitrov, Mardy Fish and Frederik Nielsen in the group stages.

He ended the year participating in the 2012 Davis Cup Final playing in both singles and doubles and winning two matches as the Czech Republic won against Spain.

[58] At the Queen's club championship, Berdych joined forces with Ivan Lendl in a charity doubles match against Andy Murray and Tim Henman, which they eventually lost 6–4.

However, Berdych bounced back at the Western & Southern Open, pulling off an upset in the quarterfinals by defeating Andy Murray but lost in the semifinals to Rafael Nadal.

Berdych reached the quarterfinals of the French Open, most notably beating John Isner in the fourth round before losing in straight sets to in-form Ernests Gulbis.

Berdych then participated in the Monte Carlo Masters, in which he defeated Gaël Monfils and Milos Raonic to reach the final, but eventually lost to Novak Djokovic.

However, Berdych's campaign ended in the quarterfinals where he lost to Roger Federer in straight sets thus failing to reach the semifinals at the Australian Open for the first time since 2013.

He did make the quarterfinals at Roland Garros, beating Pablo Cuevas and David Ferrer before losing in straight sets to eventual champion Novak Djokovic.

[66] Berdych returned to action on the Asian swing, reaching the semifinals in St. Petersburg and winning the title in Shenzhen over Richard Gasquet before suffering early losses in Tokyo and Shanghai.

Berdych played excellently at the first Lyon Open to be held since 2009,[68] beating Gilles Simon and Milos Raonic on his way to the final, only to be beaten by Tsonga, all matches being straight sets.

Having seen off the likes of Dominic Thiem and Novak Djokovic in earlier rounds at Wimbledon, Berdych succumbed in the semifinal to a superb Roger Federer, who went on to win the Championship.

After playing for Team Europe in the inaugural Laver Cup, hosted in Berdych's home capital Prague, the Czech shut down his season early with a back injury after losing in the round of 16 at Beijing.

In the third and fourth rounds Berdych beat Juan Martín del Potro and Fabio Fognini both in straight sets before losing in the quarterfinals to Roger Federer.