[4] The table of contents lists the follow sections:[5] The new module was announced in June 2017 during the Stream of Annihilation livestreamed event on the Wizards of the Coast's Twitch site.

[7] Polygon reported that "Wizards of the Coast enlisted more playtesters to try the Dungeons & Dragons Tomb of Annihilation module than any adventure it has released before.

[12] WizKids, a Wizards of the Coast licensee, released 44 pre-painted miniatures that correspond with the adventure including the lich Acererak.

[15][16] Alex Springer, for SLUG Magazine, reported that the "Tomb of Annihilation is the type of campaign that can bring out the best—or worst—in a dungeon master" and highlighted mechanics such as new character backgrounds, exploration checks, the jungle themed creature appendix, and the lingering threat of permadeath due to the Soulmonger artifact.

Springer wrote "When stacked up against Storm King’s Thunder, Tomb of Annihilation feels blessedly streamlined and adventure-focused.

[3] Cameron Kunzelman, for Paste, highlighted that the adventure is unique compared to previous modules and that the jungles of Chult are designed to try and kill you.

Kunzelman wrote "However, it is important to note that the jungles and dangers also have a slight feel of 'darkest Africa' to them, and the Chultan people are dark-skinned.

The narrative beats in Tomb pull heavily from familiar sources like Edgar Rice Burroughs or Jules Verne, and those works have a long racialized history that is not often grappled with.

Its setting is an amalgamation of African cultures, a trope frequent in 20th century media that flattens the dimensionality of human experiences on the continent, which contains hundreds of ethnic groups".