[2] Thousands of people congregate in online communities to support one another throughout the healing process, and cases have been reported in both adults and children.

[9] Other symptoms include nerve pain, insomnia, excessive sweating, anxiety, depression, fatigue, eye problems, and frequent infections.

[citation needed] The duration of acute topical corticosteroid withdrawal is variable; the skin can take months to years to return to its original condition.

In addition, the erythema characteristic of ‘red skin syndrome’ is due to a release of stored endothelial nitric oxide (NO) and subsequent vasodilation of dermal vessels.

[2] Specific signs include "headlight sign" (redness of the lower part of the face but not the nose or the area around the mouth), "red sleeve" (a rebound eruption stopping abruptly at the lower arms and hands), and "elephant wrinkles" (reduced skin elasticity).

[citation needed][dubious – discuss] Avoid moisturizer, as any dampness elongates the healing process and encourages bacterial growth.

[2][3][11] At this time, treatment options that have been documented in literature include tacrolimus, pimecrolimus, and dupilumab (Dupixent).

[8][clarification needed] A systematic review (meta-analysis) in accordance with evidence-based medicine frameworks and current research standards for clinical decision-making was performed in 2016 and was republished with updates in 2020.