Saeki deliberately avoided the public eye because, in his opinion, this allowed him to be freer and more provocative in his art.

[1] Saeki's works often depict sexuality and brutality in a very explicit way, combining traditional Shunga and Yōkai styles with elements of Western art.

During his Tokyo period, his publications included the book Saeki Toshio Gashū (佐伯俊男画集) in 1970, and some of his sketches appeared in the men's magazine Heibon Punch (平凡パンチ).

The cover of John Lennon and Yoko Ono's 1972 album Some Time in New York City features a drawing by Saeki of a devil-like figure attacking a young woman in school uniform with a knife.

[5] Toshio Saeki has had exhibitions in San Francisco, Tel Aviv, Toronto, and Taipei, among others, as well as at Art Basel Hong Kong[2]