It is now located in Totsuka-ku in the present-day city of Yokohama, Kanagawa Prefecture, Japan.
Because Totsuka-juku was approximately one day's journey from Nihonbashi, it was a very common resting place for travelers at the start of the journey and the largest post station after Odawara-juku.
During the Bakumatsu period, when Commodore Matthew C. Perry arrived in Uraga Harbor with his Black Ships, many frightened citizens fled to Totsuka-juku.
The classic ukiyo-e print by Andō Hiroshige (Hōeidō edition) from 1831–1834 depicts a traveler (one dismounting from a horse), entering into a tea-house.
In the background, a wooden bridge leads across a stream to what appears to be a sizeable settlement.