Transrectal ultrasonography, or TRUS in short, is a method of creating an image of organs in the pelvis, most commonly used to perform an ultrasound-guided needle biopsy evaluation of the prostate gland in men with elevated prostate-specific antigen or prostatic nodules on digital rectal exam.

TRUS-guided biopsy may reveal prostate cancer, benign prostatic hyperplasia, or prostatitis.

TRUS may also detect other diseases of the lower rectum and can be used to stage primary rectal cancer.

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