In 2018 Tre Fiori was the first team from San Marino to qualify for the next round of a UEFA competition, winning 3–1 against Bala Town F.C.

The club first won the Campionato Sammarinese di Calcio in 1988 winning on penalties (6-5p) against S.S. Virtus in the play-off finals after a 3–3 draw.

In the 2003–2004 season, Tre Fiori missed out on to the third position to qualify for the championship play-offs and finished fourth, three points behind S.S. Virtus.

Tre Fori defeated A.C. Juvenes/Dogana 3–1 in a penalty shootout, winning the championship play-offs and qualifying for the UEFA Champions League.

Tre Fiori had their first experience in a UEFA Champions League fixture, contesting a first qualifying round tie against UE Sant Julià from Andorra.

Tre Fiori contested in the first qualifying round of the UEFA Champions League tie against FK Rudar Pljevlja from Montenegro.

The home game of the two-legged tie was played at Stadio Olimpico in Serravalle and resulted in a 3–0 defeat for Tre Fiori.

In the home game of the two-legged tie of the first qualifying round of 2011–12 UEFA Champions League held at Stadio Olimpico in Serravalle Tre Fiori lost 3–0.

[7][8] On July 5, 2018, Tre Fiori became the first Sammarinese club to win a European tie when they defeated Bala Town from Wales 3–1 on aggregate in the preliminary round of 2018–19 UEFA Europa League qualifying.

[9] On June 13, 2022, former San Marino National Team player and record goalscorer Andy Selva was appointed manager.

The Faroese side proved too strong for Tre Fiori over the two legs and won by an aggregate score of 1–0, thus bringing the European adventure to an end.

League Cups Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.