In order to sustain the fleets and the colonies they will eventually build, humanity also created plants, artificial organic lifeforms that can produce infinite, clean energy.

Many years later, the survivors of the colony fleet have built several cities on Noman's Land's surface, being totally dependent on plants to survive the hostile conditions.

As Vash tries to find a way to peacefully resolve the differences between humans and plants, he runs into the investigative reporters Meryl Stryfe and Roberto De Niro, marking the starting point of a new adventure for the three of them.

"[11] Orange animation producer, Kiyotaka Waki, commented that the project started with concept art, followed by the development of a world for the adaptation, which "wasn't just drawings, it was filled with ideas of how we could respect that old nostalgia factor and also add in the new designs."

[12] The project's development took around five years,[12] starting in 2017, as pointed out by Waki, before the broadcast debut of Orange's first non-co-produced series, Land of the Lustrous.

Kōdai Watanabe, Tetsurō Moronuki, Takahiko Abiru, Akiko Satō, Soji Ninomiya, and Yumihiko Amano designed the characters, and Tatsuya Kato composed the music.

[19] Crunchyroll has licensed the series for a global release,[20] excluding Asia, but including the Philippines, Singapore, India, Pakistan, Bhutan, Sri Lanka, Bangladesh, Nepal, Kazakhstan, and Kyrgyzstan.