In enzymology, a trypanothione-disulfide reductase (EC 1.8.1.12) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are trypanothione and NADP+, whereas its 3 products are trypanothione disulfide, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor.
The systematic name of this enzyme class is trypanothione:NADP+ oxidoreductase.
The X-ray crystal structures of trypanothione reductase enzymes from several trypanosomatids species have been solved, including those from Crithidia fasciculata, Leishmania infantum, Trypanosoma brucei and Trypanosoma cruzi.
[1][2] Examples of trypanothione reductase inhibitors include 5-Nitro-Imidazole,[3] Febrifugine,[4] Imipramine [5] and Benzoxaborole.