It is part of the Tuscola Community Unit School District 301.

[2]: 270 The first building solely for Tuscola High School was opened October 2, 1922, bounded by Sale, Niles, Overton and Indiana Streets.

[2]: 277 The high school became part of Tuscola Community Unit School District 301 in the 1940s when the unit district was approved by public referendum.

[2]: 275 Tuscola's High School athletes participate in the Central Illinois Conference and are members of the Illinois High School Association.

TCHS offers both band and chorus programs, as well as competitive quizzing.