It grew out of host Dallas Taylor's admiration for the podcast 99% Invisible and a desire to hear more stories like the ones they produced about audio design.

The podcast has covered topics such as the THX Deep Note, misophonia, the Voyager Golden Record,[3] the Shure SM7 microphone, ASMR, and advertising jingles.

"[8] The talk discussed John Cage's composition 4'33", a topic which had previously been explored in an episode of Twenty Thousand Hertz.

[12] Following a Twenty Thousand Hertz episode about audio deepfakes, host Dallas Taylor was featured in a September 2020 segment of NPR's Here & Now, discussing the topic.

[13][14] Taylor was featured in a November 2020 episode of the Popular Science podcast The Weirdest Thing I Learned This Week, discussing the use of animals noises in sound design.