Two Mile Run is a 1.41 mi (2.27 km) long first-order tributary to West Branch Tunungwant Creek.

[2] Two Mile Run rises about 3 miles (4.8 km) west-southwest of Lewis Run, Pennsylvania, and then flows northwest to meet West Branch Tunungwant Creek about 4 miles (6.4 km) west-northwest of Lewis Run, Pennsylvania.

Two Mile Run drains 0.9 square miles (2.3 km2) of area, receives about 47.6 in/year (121 cm/year) of precipitation, and is about 91.79% forested.

[3]