Two Strike is a census-designated place (CDP) in Todd County, South Dakota, United States, named after Brulé, Lakota chief Two Strike who lived at that location for a period of time.

As of the census[4] of 2000, there were 33 people, 9 households, and 7 families residing in the CDP.

The racial makeup of the CDP was 3.03% White and 96.97% Native American.

22.2% of all households were made up of individuals, and 11.1% had someone living alone who was 65 years of age or older.

There were no families and 10.3% of the population living below the poverty line, including none under 18 and none of those over 64.