[10] On September 13 of the same year, Mahle pitched five shutout innings against the St. Louis Cardinals to earn his first MLB win.

Mahle began 2018 in Cincinnati's opening rotation, but was optioned to Louisville in August before being recalled in September.

[14] Mahle had a bounceback season in 2020, registering a 2–2 record and 3.59 ERA with 60 strikeouts in 47+2⁄3 innings of work.

On August 2, 2022, the Reds traded Mahle to the Minnesota Twins in exchange for Spencer Steer, Christian Encarnacion-Strand, and Steve Hajjar.

[16] He made 4 starts for the Twins to close out the year, posting a 1–1 record and 4.41 ERA with 12 strikeouts in 16+1⁄3 innings pitched.

On January 13, 2023, Mahle agreed to a one-year, $7.5 million contract with the Twins, avoiding salary arbitration.

In an April 27 outing against the Kansas City Royals, Mahle departed after four innings with what was described as right posterior elbow soreness.