The Tyugyuene (Russian: Тюгюэне or Тюгене; Yakut: Түгүөнэ, Tügüöne) is a river in Yakutia (Sakha Republic), Russia.

It heads first a roughly northern direction to the east of the Lungkha in its upper course, then it bends northeastwards in its middle course across the Central Yakutian Lowland, changing again to northwards.

[3][1] The A331 highway has a bridge over the Tyugyuene[4] and a gas pipeline crosses the river about 111 km (69 mi) upstream from its mouth.

[2] The vegetation of the Tyunyuene basin is mainly spruce and larch taiga, dense in some stretches of the upper course.

Since there is little human presence in the area, Eurasian eagle-owl, elk, forest reindeer, roe deer, wolf, hare, sable and muskrat are common in the river basin.