U.S. Route 15 (US 15) is a part of the United States Numbered Highway System that runs from Walterboro, South Carolina, to Painted Post, New York.

US 15 passes through a partial cloverleaf interchange with the US 58 bypass, then becomes an undivided highway on entering the town of Clarksville as College Street and crossing over the rail line.

US 15 and SR 49 turn north, cross over the Virginia Southern rail line, and parallel the eastern shore of the lake until the two highways split at the hamlet of Dortch Store.

[1][3] US 15 heads north, crossing the Bluestone Creek arm of the reservoir and entering Charlotte County, where the road becomes Barnesville Highway.

US 15 and US 360 meet SR 40 (Lunenburg County Highway) at a diamond interchange just east of the town of Keysville.

[1][3] US 15 enters Prince Edward County as Farmville Road and crosses over Norfolk Southern Railway's Blue Ridge District west of the hamlet of Briery.

US 15 meets the southern end of SR 20 (Constitution Route) then passes through the town of Dillwyn as Oak and Main streets.

After passing through Arvonia, the highway crosses the James River at New Canton on the John H. Cocke Memorial Bridge.

The U.S. Highway becomes concurrent with SR 6 (River Road) adjacent to Fork Union Military Academy.

US 15 passes through Wildwood and Hunters before intersecting US 250 (Three Notch Road) at Zion Crossroads at the Fluvanna–Louisa county line.

US 15 continues north along the edge of Green Springs National Historic Landmark District to its intersection with SR 22 (Louisa Road) at Boswells Tavern.

US 15 and US 33 veer onto Main Street and pass the Exchange Hotel at their underpass of the Washington Subdivision, the Charlottesville–Orange rail line owned by the Buckingham Branch Railroad.

US 15 meets SR 20 (Berry Hill Road) and runs concurrently with the state highway as a two-lane street under Norfolk Southern Railway's Washington District.

North of Locust Dale, US 15 crosses the Robinson River and its tributary Crooked Run; at the latter stream, the U.S. Highway enters Culpeper County.

The highways parallel the Washington District through Brandy Station and by Culpeper Regional Airport to the town of Remington, where the road crosses the Rappahannock River into Fauquier County.

Immediately north of the northern junction with the business routes, US 15 and US 29 meet the southern end of SR 28 (Catlett Road), which follows the rail line toward Manassas.

North of Bull Run, where the road enters Loudoun County, the highway passes through a pair of roundabouts at Gilberts Corner.

[1][3] At Virts Corner east of Hogback Mountain, US 15 enters the town of Leesburg as South King Street.

North of Lucketts, the U.S. Highway veers to the west and runs along the eastern flank of Furnace Mountain.

The SR 32 designation was dropped in the 1933 state highway renumbering and was immediately reused on another route south of Petersburg.

From June 2013 to February 2014, the Virginia Department of Transportation converted the existing interchange between US 15 and I-64, in Zion Crossroads, to a DDI, the first in the state, with final construction completed by mid-April 2014.