US 160 begins at a junction with US 89 north of Cameron and exits the state into New Mexico south of the Four Corners Monument.

Along its journey, the route connects the communities of Tuba City, Moenkopi, Rare Metals, Tonalea, Tsegi, Kayenta, Dennehotso, Mexican Water, Red Mesa, and Teec Nos Pos.

[3] After the junction with SR 264, US 160 continues east to the edge of town, then heads northeast, and passes through Tonalea.

US 160 stops paralleling the tracks of the Black Mesa and Lake Powell Railroad, which end at a loop west of Tsegi.

At the intersection with Navajo Route 59 (N59) near Church Rock Valley, US 160 turns to the northeast, passing through Dennehotso and crossing a bridge over Laguña Creek.

[3] US 64 continues straight ahead from the intersection, where US 160 turns to the left, heading north-by-northeast, before curving northeast and crossing into New Mexico near Four Corners Monument.

The first contract for the construction of N1 past Tuba City was awarded by the Bureau of Indian Affairs (BIA) on July 3, 1959 to the C.R.

[7] The reconstructed segment from Teec Nos Pos to the New Mexico state line became SR 364 on September 9, 1961.

Nationally, US 164 encompassed the entire length of the Navajo Trail between US 666 in Colorado and US 89 in Arizona, as well as running concurrently with US 89 southwest to a western terminus at US 66 near Flagstaff.