After the mainline of the route was shifted on to the Mount Nittany Expressway (whose western portion is now also part of Interstate 99), the business designation came into place.

The entire route is known as Atherton Street, which begins in the west as a four-lane road that is mostly bordered by residential development.

After passing by the southern entrance to Penn State University, the highway narrows to two lanes through the town center.

West of downtown, the route is four lanes and offers a mix of periodic commercial development and more rural scenes.

The business route begins at US 322 northwest of the borough and heads southeast, entering West Chester on Hannum Avenue.

was designated PA 5 heading northwest of West Chester and US 122/PA 29 (later US 202) along High Street.

is a 1.47-mile (2.37 km) business route following the former alignment of US 322 through the community of Mullica Hill in Harrison Township, Gloucester County, New Jersey.

reaches its eastern terminus at an intersection with US 322/CR 536A and CR 623, at which point Mullica Hill Road continues east as US 322/CR 536.

[13][15] Major intersections The entire route is in Harrison Township, Gloucester County.