It goes north as a four-lane divided highway, concurrent with US 70/SR 1, to leave downtown and pass through industrial areas to have a signalized intersection with State Street.

It then curves to the north and US 70/SR 1 immediately split off and go east along Airways Boulevard towards McKellar-Sipes Regional Airport.

US 45 Bypass continues through suburban neighborhoods to pass through a business district before having an interchange with Hollywood Drive.

They continue south as a six-lane divided highway for about 1 mile (1.6 km) before coming to an interchange with Highland Street, where US 45/SR 5 branch off and SR 186 follows US 45 Bypass.

It would route through traffic away from the central business district and give another crossing for South Jackson commuters.