U.S. Route 63 (US 63) is a highway in southeastern Minnesota that runs from the Minnesota-Iowa border south of Spring Valley to the Mississippi River at Red Wing.

It travels north to Spring Valley where it becomes concurrent with State Highway 16, following it west for five miles entering Mower County.

A short segment of the highway is built to four-lane expressway standards just north of Zumbro Falls.

[4][5] The route had previously been marked the year before as U.S. 59, except for the segment running from U.S. 61 to the river crossing, which had been State Highway 58.

This makes the route longer, but reduces transit time due to higher speed limits and fewer traffic lights.